This book provides the readers with an up-to-date review of the design, structure and function of a representative selection of fibrous proteins in both health and disease.
The importance of the α-helical coiled coil, a conformational motif based on the heptad repeat in the amino acid sequence of all α-fibrous proteins (and parts of some globular proteins) is underlined by three
Chapters devoted to its design, structure, function and topology. Specific proteins covered in the text and which depend on the coiled coil for their structure and function, include the intermediate filament proteins, tropomyosin, myosin, paramyosin, fibrin and members of the spectrin superfamily.
Also described are fibrous proteins based on the β-pleated sheet and collagen conformations.
Recombinant structural proteins, especially of silk and collagen, are discussed in the context of developing new biomaterials with varied applications.